Anosognosia en la enfermedad de Alzheimer y el deterioro cognitivo leve: una revisión sistemática

/ Vol 9-Nº 1 ene-jun 2026 /

Pablo Jordán de Urries Bonal1; Francisco Ramos Campos2 y Francisco de Borja Jordán de Urries Vega3

ABSTRACT

Introduction:: Anosognosia, or lack of disease awareness, is common in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). It has implications for the clini-cal and quality of life (QoL) of sufferers and caregivers. Its understanding is crucial for early diagnosis and intervention.

Methods: Systematic review of studies between 2016 and 2024 in PubMed/Med-line, PsycINFO, and CINAHL with inclusion criteria and assessment of methodolog-ical rigor with the Newcastle-Ottawa Scale.

Results: 12 studies included. Anosognosia in people with AD and MCI appears to be associated with higher prevalence and severity of psychological and behavioral symptoms of dementia, faster disease progression, and significant reduction in QOL in patients and caregivers. The most common measurement instruments were the
AQ-D and the ECOG.

Conclusions: Anosognosia has a significant impact on people with AD and MCI and their caregivers. There is heterogeneity in the measurement instruments, and there is a need for standardized and accurate tools. Further research is crucial to improve clinical management strategies and caregiver support.

1 Universidad de Salamanca. pablojub@usal.es
2 Universidad de Salamanca. frc@usal.es
3 Instituto Universitario de Integración en la Comunidad, INICO – Universidad de Salamanca.
bjordan@usal.es

*Corresponding author:

Francisco de Borja Jordán de Urries Vega
Instituto Universitario de Integración en la Comunidad, INICO
– Universidad de Salamanca, Facultad de Psicología, Avenida de la Merced 109-131, 37005, Sala-manca, España; +34 670576812;
bjordan@usal.es

Key words:

Anosognosia, Alzheimer’s disease mild cognitive impairment, psychological and behavioral symptoms, quality of life.

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